intranasal delivery of camptothecin-loaded tat-modified nanomicells for treatment of intracranial brain tumors鼻内交付camptothecin-loaded tat-modified nanomicells颅内脑肿瘤的治疗.pdfVIP

下载本文档

1
0
约3.36万字
约 11页
2017-09-11 发布于上海
举报
版权申诉

intranasal delivery of camptothecin-loaded tat-modified nanomicells for treatment of intracranial brain tumors鼻内交付camptothecin-loaded tat-modified nanomicells颅内脑肿瘤的治疗.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

intranasal delivery of camptothecin-loaded tat-modified nanomicells for treatment of intracranial brain tumors鼻内交付camptothecin-loaded tat-modified nanomicells颅内脑肿瘤的治疗

Pharmaceuticals 2012, 5, 1092-1102; doi:10.3390/ph5101092 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Article Intranasal Delivery of Camptothecin-Loaded Tat-Modified Nanomicells for Treatment of Intracranial Brain Tumors Hiroyuki Taki †, Takanori Kanazawa †,*, Fuminari Akiyama, Yuuki Takashima and Hiroaki Okada School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: kanazawa@toyaku.ac.jp; Tel./Fax: +81-42-676-4493. Received: 3 September 2012; in revised form: 27 September 2012 / Accepted: 9 October 2012 / Published: 15 October 2012 Abstract: The blood-brain barrier is a substantial obstacle for delivering anticancer agents to brain tumors, and new strategies for bypassing it are sorely needed for brain tumor therapy. Intranasal delivery provides a practical, noninvasive method for delivering therapeutic agents to the brain. Intranasal application of nano-sized micelles that have been modified with Tat peptide facilitates brain delivery of fluorescent model materials. In this study, we evaluated a nose-to-brain delivery system for brain tumor therapy. We nasally administered the anti-tumor drug camptothecin (CPT) in solution and in methoxy poly(ethylene glycol) (MPEG)/poly(-caprolactone) (PCL) amphiphilic block copolymers (MPEG-PCL) and cell penetrating peptide, Tat analog-modified