neonatal calf infection with respiratory syncytial virus drawing parallels to the disease in human infants新生儿小牛感染呼吸道合胞体病毒在人类婴儿疾病的共性.pdfVIP

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neonatal calf infection with respiratory syncytial virus drawing parallels to the disease in human infants新生儿小牛感染呼吸道合胞体病毒在人类婴儿疾病的共性.pdf

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neonatal calf infection with respiratory syncytial virus drawing parallels to the disease in human infants新生儿小牛感染呼吸道合胞体病毒在人类婴儿疾病的共性

Viruses 2012, 4, 3731-3753; doi:10.3390/v4 123731 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review Neonatal Calf Infection with Respiratory Syncytial Virus: Drawing Parallels to the Disease in Human Infants Randy E. Sacco 1,*, Jodi L. McGill 1, Mitchell V. Palmer 2, John D. Lippolis 1, 1 1 Timothy A. Reinhardt and Brian J. Nonnecke 1 Ruminant Diseases and Immunology Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa, 50010, USA ; E-Mails: Jodi.McGill@ (J.L.M.); John.Lippolis@ (J.D.L.); Tim.Reinhardt@ (T.A.R.); Brian.Nonnecke@ (B.J.N.) 2 Infectious Bacterial Diseases Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa, 50010, USA; E-Mail: Mitchell.Palmer@ * Author to whom correspondence should be addressed; E-Mail: Randy.Sacco@; Tel.: +1-515-337-7354; Fax: +1-515-337-7149. Received: 1 November 2012; in revised form: 29 November 2012 / Accepted: 7 December 2012 / Published: 13 December 2012 Abstract: Respiratory syncytial virus (RSV) is the most common viral cause of childhood acute lower respiratory tract infections. It is estimated that RSV infections result in more than 100,000 deaths annually worldwide. Bovine RSV is a cause of enzootic pneumonia in young dairy calves and summer pneumonia in nursing beef calves. Furthermore, bovine RSV plays a significant role in