原创力文档neonatal outcomes among multiple births ≤ 32 weeks gestational age does mode of conception have an impact a cohort study新生儿的结果在多胞胎≤32周胎龄的概念模式有一个队列研究产生影响.pdfVIP
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neonatal outcomes among multiple births ≤ 32 weeks gestational age does mode of conception have an impact a cohort study新生儿的结果在多胞胎≤32周胎龄的概念模式有一个队列研究产生影响
Shah et al. BMC Pediatrics 2011, 11:54
/1471-2431/11/54
RESEARCH ARTICLE Open Access
Neonatal outcomes among multiple births
≤ 32 weeks gestational age: Does mode of
conception have an impact? A Cohort Study
1* 1 1 2 1
Vibhuti Shah , Haydi AlWassia , Karan Shah , Woojin Yoon and Prakeshkumar Shah
Abstract
Background: Studies comparing perinatal outcomes in multiples conceived following the use of artificial
reproductive technologies (ART) vs. spontaneous conception (SC) have reported conflicting results in terms of
mortality and morbidity. Therefore, the objective of our study was to compare composite outcome of mortality
and severe neonatal morbidities amongst preterm multiple births ≤ 32 weeks gestation infant born following
ART vs. SC.
Methods: We conducted a single center cohort study at Mount Sinai Hospital, Toronto, Ontario, Canada. Data on
all preterm multiple births (≤ 32 weeks GA) discharged between July 2005 and June 2008 were retrospectively
collected from a prospective database at our centre. Details regarding mode of conception were collected
retrospectively from maternal health records. Preterm multiple births were categorized into those born following
ART vs. SC. Composite outcome was defined as combination of death or any of the three neonatal morbidities
(grade 3/4 intraventricular hemorrhage or periventricular leukomalacia; retinopathy of prematurity stage 2 or
chronic lung disease). Univariate and multivariate regression analysis were preformed after adjustment of
confounders (maternal age, parity, triplets, gestational age, sex, and small for gestational age).
Results: One hundred and thirty seven neonates were born following use of ART and 233 following SC. The
unadjusted compo
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