new furanones from the plant endophytic fungus pestalotiopsis besseyi植物内生真菌的新furanones pestalotiopsis besseyi.pdfVIP

Molecules 2012, 17, 14015-14021; doi:10.3390/molecules171214015 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article New Furanones from the Plant Endophytic Fungus Pestalotiopsis besseyi Haitao Liu 1, Shuchun Liu 2,3, Liangdong Guo 3, Yonggang Zhang 4, Langjun Cui 5 and Gang Ding 1,* 1 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 2 Graduate School of Chinese Academy of Sciences, Beijing 100086, China 3 Institute of Microbiology, Beijing 100086, China 4 Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, Shandong, China 5 College of Life Science, Shaanxi Normal University, Xi’an 710062, Shaanxi, China * Author to whom correspondence should be addressed; E-Mail: gding@ or dgfyhchina@163.com; Tel.: +86-010-5783-3281; Fax: +86-010-5783-3290. Received: 24 October 2012; in revised form: 22 November 2012 / Accepted: 23 November 2012 / Published: 27 November 2012 Abstract: Pestalafuranones A–E (compounds 1–5), five new 2(5H)-furanones, have been isolated from cultures of an isolate of Pestalotiopsis besseyi . The structures of these compounds were elucidated mainly by analysis of their NMR spectroscopic data and HRESIMS experiments. Pestalafuranones A–C (compounds 1–3) displayed weak inhibitory effects against HIV-1 replication in C8166 cells, whereas pestalafuranones D (4) and E (5) showed