new horizons and perspectives in the treatment of osteoarthritis新视野和角度治疗骨关节炎.pdfVIP

Available online /supplements/10/S2/S1 Review New horizons and perspectives in the treatment of osteoarthritis Francis Berenbaum Pierre Marie Curie Paris 6 University, Department of Rheumatology, APHP Saint-Antoine Hospital, 184 rue du faubourg Saint-Antoine, 75012 Paris, France Corresponding author: Francis Berenbaum, francis.berenbaum@sat.aphp.fr Published: 17 October 2008 Arthritis Research Therapy 2008, 10(Suppl 2):S1 (doi:10.1186/ar2462) This article is online at /supplements/10/S2/S1 © 2008 BioMed Central Ltd Abstract the current armamentarium of available therapies, develop- Osteoarthritis (OA) is increasingly prevalent worldwide and is ment of new agents with potentially improved safety profiles associated with a significant economic burden. Despite the may offer new alternatives for these patients. increasing number of patients with OA, treatments to manage the condition remain symptomatic, designed to control pain, and Burden of osteoarthritis improve function and quality of life while limiting adverse events. Functional burden Both the EULAR (European League Against Rheumatism) and the OA imposes a significant functional burden on affected indivi- OARSI (Osteoarthritis Research Society International) issued new duals. NHANES III (the Third National Health and Nutrition guidelines in 2007 and 2008 recommending a combination of nonpharmacological and pharmacological modalities to manage Examination Stud