new insights into htlv-1 particle structure, assembly, and gag-gag interactions in living cells新见解htlv 1粒子结构、装配和gag-gag在活细胞的相互作用.pdfVIP

Viruses 2011, 3, 770-793; doi:10.3390/v3060770 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review New Insights into HTLV-1 Particle Structure, Assembly, and Gag-Gag Interactions in Living Cells Keir H. Fogarty 1,4, Wei Zhang 1,2, Iwen F. Grigsby 1,2, Jolene L. Johnson 4, Yan Chen 1,4, Joachim D. Mueller 1,4,5 and Louis M. Mansky 1,2,3,* 1 Institute for Molecular Virology, University of Minnesota, Minneapolis, 18-242 Moos Tower, 515 Delaware St. SE, Minneapolis, MN 55455, USA; E-Mails: fogarty@ (K.H.F.); zhangwei@ (W.Z.); grigs011@ (I.F.G.); chen@ (Y.C.); mueller@(J.D.M.) 2 Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA 3 Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455 , USA 4 School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, USA; E-Mail: john4580@(J.L.J .) 5 Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA * Author to whom correspondence should be addressed; E-Mail: mansky@ (L.M.M.); Tel.: +1-612-626-5525; Fax: +1-612-626-5515. Received: 15 April 2011; in revised form: 20 May 2011 / Accepted: 20 May 2011 / Published: 14 June 2011 Abstract: Human T-cell leukemia virus type 1 (HTLV-1) has a reputation for being extremely difficult to study in cell culture. The challenges in propagating HTLV-1 has prevented a rigorous analysis of how these viruses replicate in cells, including the detailed steps involved i