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nosocomial infections and immunity lesson from brain-injured patients从脑损伤患者院内感染和免疫教训
Critical Care August 2004 Vol 8 No 4 Dziedzic et al.
Review
Nosocomial infections and immunity: lesson from brain-injured
patients
Tomasz Dziedzic, Agnieszka Slowik and Andrzej Szczudlik
Department of Neurology, Jagiellonian University, Krakow, Poland
Corresponding author: Tomasz Dziedzic, dziedzictom@mediclub.pl or Dziedzic@neuro.cm-uj.krakow.pl
Published online: 19 February 2004 Critical Care 2004, 8:266-270 (DOI 10.1186/cc2828)
This article is online at /content/8/4/266
© 2004 BioMed Central Ltd
Abstract
Of brain-injured patients admitted to intensive care units, a significant number acquires nosocomial
infections. Increased susceptibility to infectious agents could, at least partly, be due to transient
immunodepression triggered by brain damage. Immune deficiency in patients with severe brain injury
primarily involves T cell dysfunction. However, humoral and phagocytic deficiencies are also
detectable. Activation of the hypothalamo–pituitary–adrenal axis and the sympathetic nervous system
plays a crucial role in brain-mediated immunodepression. In this review we discuss the role of
immunodepression in the development of nosocomial infections and clinical trials on
immunomodulation in brain-injured patients with hospital-acquired infections.
Keywords brain injury, immunodepression, infection, intensive care
Introduction pneumonia was 21%. Be
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