原创力文档placental transfer of the polybrominated diphenyl ethers bde-47, bde-99 and bde-209 in a human placenta perfusion system an experimental study胎盘转移bde-47苯醚,12 - 99 - 12 - 99在人类胎盘灌注系统的实验研究.pdfVIP
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placental transfer of the polybrominated diphenyl ethers bde-47, bde-99 and bde-209 in a human placenta perfusion system an experimental study胎盘转移bde-47苯醚,12 - 99 - 12 - 99在人类胎盘灌注系统的实验研究
Frederiksen et al. Environmental Health 2010, 9:32
/content/9/1/32
R E S E A R C H Open Access
Research
Placental transfer of the polybrominated diphenyl
ethers BDE-47, BDE-99 and BDE-209 in a human
placenta perfusion system: an experimental study
†1,2,3 †2 1 1 1
Marie Frederiksen , Katrin Vorkamp , Line Mathiesen , Tina Mose and Lisbeth E Knudsen*
Abstract
Background: Polybrominated diphenyl ethers (PBDEs) have been widely used as flame retardants in consumer
products. PBDEs may affect thyroid hormone homeostasis, which can result in irreversible damage of cognitive
performance, motor skills and altered behaviour. Thus, in utero exposure is of very high concern due to critical
windows in fetal development.
Methods: A human ex vivo placenta perfusion system was used to study the kinetics and extent of the placental
transfer of BDE-47, BDE-99 and BDE-209 during four-hour perfusions. The PBDEs were added to the maternal
circulation and monitored in the maternal and fetal compartments. In addition, the perfused cotyledon, the
surrounding placental tissue as well as pre-perfusion placental tissue and umbilical cord plasma were also analysed.
The PBDE analysis included Soxhlet extraction, clean-up by adsorption chromatography and GC-MS analysis.
Results and Discussion: Placental transfer of BDE-47 was faster and more extensive than for BDE-99. The fetal-
maternal ratios (FM-ratio) after four hours of perfusion were 0.47 and 0.25 for BDE-47 and BDE-99, respectively, while
the indicative permeability coefficient (IPC) measured after 60 minutes of perfusion was 0.26 h-1 and 0.10 h-1,
respectively. The transport of BDE-209 seemed to be limited. These differences between the congeners may be relat
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