polyunsaturated fatty acid intake and prevalence of eczema and rhinoconjunctivitis in japanese children the ryukyus child health study多不饱和脂肪酸摄入量和流行日本儿童的湿疹和rhinoconjunctivitis琉球儿童健康研究.pdfVIP

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polyunsaturated fatty acid intake and prevalence of eczema and rhinoconjunctivitis in japanese children the ryukyus child health study多不饱和脂肪酸摄入量和流行日本儿童的湿疹和rhinoconjunctivitis琉球儿童健康研究.pdf

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polyunsaturated fatty acid intake and prevalence of eczema and rhinoconjunctivitis in japanese children the ryukyus child health study多不饱和脂肪酸摄入量和流行日本儿童的湿疹和rhinoconjunctivitis琉球儿童健康研究

Miyake et al. BMC Public Health 2011, 11:358 /1471-2458/11/358 RESEARCH ARTICLE Open Access Polyunsaturated fatty acid intake and prevalence of eczema and rhinoconjunctivitis in Japanese children: The Ryukyus Child Health Study 1* 1 2 3 Yoshihiro Miyake , Keiko Tanaka , Satoshi Sasaki and Masashi Arakawa Abstract Background: The recent increase in the prevalence of allergic disorders might be a consequence of increased intake of n-6 polyunsaturated fatty acids (PUFAs) and reduced intake of n-3 PUFAs. The current cross-sectional study examined the association between intake levels and the prevalence of eczema and rhinoconjunctivitis in Japanese children. Methods: Subjects were 23,388 schoolchildren aged 6-15 years residing in Okinawa. The presence of eczema and/ or rhinoconjunctivitis was determined according to the criteria of the International Study of Asthma and Allergies in Childhood. A brief diet history questionnaire for children and adolescents was administered to acquire information on dietary factors. Adjustment was made for age, sex, residential municipality, number of siblings, smoking in the household, body mass index, paternal and maternal history of allergic diseases, and paternal and maternal educational level. Results: The prevalences of eczema and rhinoconjunctivitis in the previous 12 months were 7.0% and 8.0%, respectively. Consumption of PUFAs, n-3 PUFAs, a-linolenic acid, n-6 PUFAs, and linoleic acid was positively associated with the prevalence of eczema: the adjusted odds ratios (ORs) between extreme quintiles (95% confidence intervals [CIs], P for trend) were 1.26 (1.07-1.48, 0.04), 1.31 (1.11-1.54, 0.009), 1.31 (1.12-1.55, 0.003), 1.26 (1.07-1.48, 0.01), and 1.27 (1.08-1.49, 0.01), respectively.