physiologically based pharmacokinetic modeling of arterial – antecubital vein concentration difference基于生理药代动力学建模的动脉u2014u2014肘前的静脉浓度差.pdfVIP

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physiologically based pharmacokinetic modeling of arterial – antecubital vein concentration difference基于生理药代动力学建模的动脉u2014u2014肘前的静脉浓度差.pdf

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physiologically based pharmacokinetic modeling of arterial – antecubital vein concentration difference基于生理药代动力学建模的动脉u2014u2014肘前的静脉浓度差

BMC Clinical Pharmacology BioMed Central Research article Open Access Physiologically based pharmacokinetic modeling of arterial – antecubital vein concentration difference David G Levitt* Address: Department of Physiology, University of Minnesota, Minneapolis, Minnesota, U.S.A Email: David G Levitt* - levit001@ * Corresponding author Published: 19 February 2004 Received: 02 September 2003 Accepted: 19 February 2004 BMC Clinical Pharmacology 2004, 4:2 This article is available from: /1472-6904/4/2 © 2004 Levitt; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Modeling of pharmacokinetic parameters and pharmacodynamic actions requires knowledge of the arterial blood concentration. In most cases, experimental measurements are only available for a peripheral vein (usually antecubital) whose concentration may differ significantly from both arterial and central vein concentration. Methods: A physiologically based pharmacokinetic (PBPK) model for the tissues drained by the antecubital vein (referred to as arm) is developed. It is assumed that the arm is composed of tissues with identical properties (partition coefficient, blood flow/gm) as the whole body tissues plus a new tissue representing skin arteriovenous shunts. The antecubital vein concentration