practical dynamic contrast enhanced mri in small animal models of cancer data acquisition, data analysis, and interpretation实际动态对比增强磁共振成像在小动物模型的癌症数据采集、数据分析和解释.pdfVIP

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practical dynamic contrast enhanced mri in small animal models of cancer data acquisition, data analysis, and interpretation实际动态对比增强磁共振成像在小动物模型的癌症数据采集、数据分析和解释.pdf

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practical dynamic contrast enhanced mri in small animal models of cancer data acquisition, data analysis, and interpretation实际动态对比增强磁共振成像在小动物模型的癌症数据采集、数据分析和解释

Pharmaceutics 2012, 4, 442-478; doi:10.3390/pharmaceutics4030442 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Review Practical Dynamic Contrast Enhanced MRI in Small Animal Models of Cancer: Data Acquisition, Data Analysis, and Interpretation Stephanie L. Barnes 1,2, Jennifer G. Whisenant 1,3 , Mary E. Loveless 1 and Thomas E. Yankeelov 1,2,3,4,5,6,7,* 1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, 37232-2310, USA; E-Mails: steph.barnes@ (S.L.B.); j.whisenant@ (J.G.W.); mary.loveless@ (M.E.L.) 2 Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA 3 Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN 37232, USA 4 Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235-1826, USA 5 Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA 6 Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232-6838, USA 7 Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA * Author to whom correspondence should be addressed; E-Mail: thomas.yankeelov@; Tel.: +1-615-322-8354 Fax: +1-615-322-0734. Received: 20 July 2012; in revised form: 1 September 2012 / Accepted: 10 September 2012 / Published: 19 September 2012 Abstract: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) consists of the continuous acquisition of images before, during, and after the injection of a contrast agent. DCE-MRI allows for noninvasive evaluation of tumor parameters related to vascular perfusion and pe