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protein traffic is?an intracellular target in alcohol toxicity蛋白质交通酒精毒性细胞内的目标
Pharmaceuticals 2011, 4, 741-757; doi:10.3390/ph4050741
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
Protein Traffic Is an Intracellular Target in Alcohol Toxicity
Guillermo Esteban-Pretel 1, María Pilar Marín 1, Ana M. Romero 1, Xavier Ponsoda 2, Raul
Ballestin 2, Juan J. Canales 3 and Jaime Renau-Piqueras 1,*
1 Sección de Biología y Patología Celular, Centro de Investigación, IIS-La Fe, Valencia, Spain;
E-Mails: esteban_gui@gva.es (G.E.-P.); marin_mpm@gva.es (M.P.M.); amarope@alumni.uv.es
(A.M.R.); renau_jai@gva.es (J.R.-P.)
2 Department of Biología Celular, Universidad de Valencia, Valencia, Spain;
E-Mails: Ponsoda@uv.es (X.P.); raul.ballestin@ (R.B.)
3 Behavioural Neuroscience, Department of Psychology, University of Canterbury, Private Bag 4800,
Christchurch 8140, New Zealand; E-Mail: juan.canales@canterbury.ac.nz (J.J.C.)
* Author to whom correspondence should be addressed; E-Mail: renau_jai@gva.es or renau@uv.es.
Received: 15 March 2011; in revised form: 3 May 2011 / Accepted: 13 May 2011 /
Published: 17 May 2011
Abstract: Eukaryotic cells comprise a set of organelles, surrounded by membranes with a
unique composition, which is maintained by a complex synthesis and transport system.
Cells also synthesize the proteins destined for secretion. Together, these processes are
known as the secretory pathway or exocytosis. In addition, many molecules can be
internalized by cells through a process called endocytosis. Chronic and acute
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