原创力文档regional differences in apd restitution can initiate wavebreak and re-entry in cardiac tissue a computational study地区差异在美国归还可以启动wavebreak和返回过程中心脏组织计算研究.pdfVIP
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regional differences in apd restitution can initiate wavebreak and re-entry in cardiac tissue a computational study地区差异在美国归还可以启动wavebreak和返回过程中心脏组织计算研究
BioMedical Engineering OnLine BioMed Central
Research Open Access
Regional differences in APD restitution can initiate wavebreak and
re-entry in cardiac tissue: A computational study
1 2
Richard H Clayton* and Peter Taggart
Address: 1Department of Computer Science, University of Sheffield, Regent Court, 211 Portobello Street, Sheffield S1 4DP, UK and 2Departments
of Cardiology and Cardiothoracic Surgery, University College Hospital, 16-18 Westmoreland Street, London W1G 8PH, UK
Email: Richard H Clayton* - r.h.clayton@sheffield.ac.uk; Peter Taggart - peter.taggart@
* Corresponding author
Published: 20 September 2005 Received: 15 July 2005
Accepted: 20 September 2005
BioMedical Engineering OnLine 2005, 4:54 doi:10.1186/1475-925X-4-54
This article is available from: /content/4/1/54
© 2005 Clayton and Taggart; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Regional differences in action potential duration (APD) restitution in the heart
favour arrhythmias, but the mechanism is not well understood.
Methods: We simulated a 150 × 150 mm 2D sheet of cardiac ventricular tissue using a simplified
computational model. We investigated wavebreak and re-entry initiated by an S1S2S3 stimulus
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