原创力文档regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis监管和血清胃促生长素浓度的重要预后相关性疾病和败血症.pdfVIP
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regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis监管和血清胃促生长素浓度的重要预后相关性疾病和败血症
Koch et al. Critical Care 2010, 14:R94
/content/14/3/R94
R E S E A R C H Open Access
Research
Regulation and prognostic relevance of serum
ghrelin concentrations in critical illness and sepsis
Alexander Koch, Edouard Sanson, Anita Helm, Sebastian Voigt, Christian Trautwein and Frank Tacke*
Abstract
Introduction: Ghrelin has been recently identified as a mediator of various beneficial effects in animal models of
sepsis. At present, no data are available concerning specific properties of ghrelin in critically ill patients from large
cohorts. In order to identify possible pathogenic functions of ghrelin in critically ill patients and human sepsis from a
clinical point of view, we aimed at analyzing ghrelin serum concentrations in a large cohort of well characterized
patients with critical illness.
Methods: A total of 170 critically ill patients (122 with sepsis, 48 without sepsis) were studied prospectively on
admission to the Medical intensive care unit (ICU) and compared to 60 healthy controls. Careful assessment of clinical
data, various laboratory parameters, metabolic and endocrine functions as well as investigational inflammatory
cytokine profiles have been performed, and patients were followed for approximately three years.
Results: Ghrelin serum concentrations are elevated in critically ill patients as compared to healthy controls, but do not
differ between sepsis and non-sepsis patients. The underlying etiologies of critical diseases are not associated with
ghrelin serum levels. Neither pre-existing diabetes mellitus nor body mass index is correlated to serum ghrelin
concentrations. Ghrelin is not correlated to markers of inflammation or hepatic function in critically ill patients. In the
subgroup of non-sepsis patients, ghrelin correlates inversely with renal function and markers of carbohydrate
m
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