regulation of sox9 activity by crosstalk with nuclear factor-κb and retinoic acid receptorssox9的监管活动通过与核factor-κb相声和视黄酸受体.pdfVIP

Available online /content/10/1/R3 Vol 10 No 1 Open Access Research article Regulation of Sox9 activity by crosstalk with nuclear factor-κB and retinoic acid receptors Jason S Rockel, Julie C Kudirka, Andrew J Guzi and Suzanne M Bernier Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, and Department of Anatomy and Cell Biology, Schulich School of Medicine Dentistry, The University of Western Ontario, London, Ontario, Canada, N6A 5C1 Corresponding author: Jason S Rockel, jeff.dixon@schulich.uwo.ca Received: 13 Sep 2007 Revisions requested: 19 Oct 2007 Revisions received: 8 Nov 2007 Accepted: 9 Jan 2008 Published: 9 Jan 2008 Arthritis Research Therapy 2008, 10:R3 (doi:10.1186/ar2349) This article is online at: /content/10/1/R3 © 2008 Rockel et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Sox9 and p300 cooperate to induce expression of factor alone. However, neither agent altered nuclear levels of cartilage-specific matrix proteins, including type II collagen, Sox9, and TNF-α did not affect protein binding to the Col2a1 aggrecan and link protein. Tumour necrosis factor (TNF)-α, 48-base-pair minimal enhancer sequence. The effect of TNF-α, found in arthritic joints, activates nuclear factor-κB (NF-κB), but not that of atRA, on Sox9 activity was dependent on NF-κB whereas retinoic acid receptors (RARs) are activated by retinoid a