seasonality of mrsa infections耐甲氧西林金黄色葡萄球菌感染的季节性.pdfVIP

Seasonality of MRSA Infections Leonard A. Mermel1,2*, Jason T. Machan3,4, Stephen Parenteau1 1 Department of Epidemiology and Infection Control, Rhode Island Hospital, Providence, Rhode Island, United States of America, 2 Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America, 3 Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America, 4 Department of Surgery, Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America Abstract Using MRSA isolates submitted to our hospital microbiology laboratory January 2001–March 2010 and the number of our emergency department (ED) visits, quarterly community-associated (CA) and hospital-associated (HA) MRSA infections were modeled using Poisson regressions. For pediatric patients, approximately 1.85x (95% CI 1.45x–2.36x, adj. p,0.0001) as many CA-MRSA infections per ED visit occurred in the second two quarters as occurred in the first two quarters. For adult patients, 1.14x (95% CI 1.01x–1.29x, adj.p = 0.03) as many infections per ED visit occurred in the second two quarters as in the first two quarters. Approximately 2.94x (95% CI 1.39x–6.21x, adj.p = 0.015) as many HA-MRSA infections per hospital admission occurred in the second two quarters as occurred in the first two quarters for pediatric patients. No seasonal variation was observed among adult HA-MRSA infections per hospital admission. We demonstrated seasonality of MRSA infections and provide a summary table of similar observations in other studies. Citation: Mermel LA, Machan JT, Parenteau S (2011) Seasonality of MRSA Infections. PLoS ONE 6(3): e17925. doi:10.1371/journal.pone.0017925 Editor: Frank DeLeo, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United S