soluble flt-1 and plgf new markers of early pregnancy loss可溶性flt-1和plgf怀孕早期损失的新标记.pdfVIP

Soluble Flt-1 and PlGF: New Markers of Early Pregnancy Loss? 1 2 2 2 2 Shanthi Muttukrishna *, Michelle Swer , Sangeeta Suri , Amna Jamil , Jean Calleja-Agius , Subrata 2 2 2 2 Gangooly , Helen Ludlow , Davor Jurkovic , Eric Jauniaux 1 Department of Obstetrics and Gynaecology, Anu Research Centre, University College Cork, Cork University Maternity Hospital, Wilton, Cork, Republic of Ireland, 2 University College London Institute for Women’s Health, University College London, London, United Kingdom Abstract Recent data have indicated a relationship between placental oxygen and angiogenic protein levels in the first trimester of normal pregnancies. Our objective was to investigate if maternal serum levels of angiogenic factors Soluble vascular endothelial growth factor (VEGF) receptor 1 (sFlt-1), soluble Endoglin and placental growth factor (PlGF) are altered in women with symptoms of threatened miscarriage (TM) and if they are predictive of a subsequent miscarriage. Blood samples were collected at 6–10 weeks from women presenting with TM (n = 40), from asymptomatic controls (n = 32) and from non- pregnant women in their luteal phase (n = 14). All samples were assayed for serum level of sFLT-1, PlGF, sEndoglin and HSP70 using commercial ELISAs. Samples were analysed retrospectively on the basis of pregnancy outcome. TM group included 21 women with a normal pregnancy outcome and 19 with subsequent complete miscarriage. The latter subgroup had significantly lower mean maternal serum (MS) sFlt-1 (83%, P,0.001) and PlGF (44%, P,0.001) compared to those with a normal pregnancy outcome. Asymptomatic control pregnan