原创力文档synapse associated protein 102 (sap102) binds the c-terminal part of the scaffolding protein neurobeachin突触相关蛋白102(sap102)结合c端脚手架蛋白neurobeachin的一部分.pdfVIP
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synapse associated protein 102 (sap102) binds the c-terminal part of the scaffolding protein neurobeachin突触相关蛋白102(sap102)结合c端脚手架蛋白neurobeachin的一部分
Synapse Associated Protein 102 (SAP102) Binds the C-
Terminal Part of the Scaffolding Protein Neurobeachin
1. 2. 1 2 1
Juliane Lauks , Patricia Klemmer , Fatima Farzana , Ramesh Karupothula , Robbert Zalm ,
4 2 2 1 1,3
Nancy E. Cooke , Ka Wan Li , August B. Smit , Ruud Toonen , Matthijs Verhage *
1 Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Amsterdam, The
Netherlands, 2 Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University
Amsterdam, Amsterdam, The Netherlands, 3 Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU
University Amsterdam and VU Medical Center, Amsterdam, The Netherlands, 4 Department of Genetics and Medicine, Perelman School of Medicine, University of
Pennsylvania, Philadelphia, Pennsylvania, United States of America
Abstract
Neurobeachin (Nbea) is a multidomain scaffold protein abundant in the brain, where it is highly expressed during
development. Nbea-null mice have severe defects in neuromuscular synaptic transmission resulting in lethal paralysis of the
newborns. Recently, it became clear that Nbea is important also for the functioning of central synapses, where it is
suggested to play a role in trafficking membrane proteins to both, the pre- and post-synaptic sites. So far, only few binding
partners of Nbea have been found and the precise mec
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