synthesis of some phenylpropanoid glycosides (ppgs) and their acetylcholinesterasexanthine oxidase inhibitory activities合成一些phenylpropanoid苷(ppg)及其acetylcholinesterasexanthine氧化酶抑制活动.pdfVIP

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synthesis of some phenylpropanoid glycosides (ppgs) and their acetylcholinesterasexanthine oxidase inhibitory activities合成一些phenylpropanoid苷(ppg)及其acetylcholinesterasexanthine氧化酶抑制活动.pdf

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synthesis of some phenylpropanoid glycosides (ppgs) and their acetylcholinesterasexanthine oxidase inhibitory activities合成一些phenylpropanoid苷(ppg)及其acetylcholinesterasexanthine氧化酶抑制活动

Molecules 2011, 16, 3580-3596; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis of Some Phenylpropanoid Glycosides (PPGs) and Their Acetylcholinesterase/Xanthine Oxidase Inhibitory Activities Xiao-Dong Li 1, Shuai-Tao Kang 1, Guo-Yu Li 2,3, Xian Li 1,4 and Jin-Hui Wang 1,2,3,4,* 1 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; E-Mail: lxdpharm@ (X.-D. L.) 2 School of Pharmacy, Shihezi University, Shihezi 832002, China 3 Key Laboratory of Phytomedicine Resources Modernization of TCM of Ministry of Education, Shihezi 832002, China 4 Key Laboratory of Structure-Based Drug Design Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China * Author to whom correspondence should be addressed; E-Mail: wjh.1972@; Tel.: +86-24 Fax: +86-024 Received: 16 March 2011; in revised form: 25 April 2011 / Accepted: 26 April 2011 / Published: 28 April 2011 Abstract: In this research, three categories of phenylpropanoid glycosides (PPGs) were designed and synthesized with PPGs isolated from Rhodiola rosea L. as lead compounds. Their inhibitory abilities toward acetylcholinesterase (AChE) and xanthine oxidase (XOD) were also tested. Some of the synthetic PPGs exhibited excellent enzyme inhibitory abilities. Keywords: phenylpropanoid glycosides; Rhodiola rosea L.; acetylcholinesterase/xanthine oxidase inhibitory activity 1. Introduction Rhodiola ros