原创力文档systematic review of mucosal immunity induced by oral and inactivated poliovirus vaccines against virus shedding following oral poliovirus challenge口服引起的粘膜免疫系统回顾和灭活脊髓灰质炎病毒疫苗病毒脱落后口服脊髓灰质炎的挑战.pdfVIP
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systematic review of mucosal immunity induced by oral and inactivated poliovirus vaccines against virus shedding following oral poliovirus challenge口服引起的粘膜免疫系统回顾和灭活脊髓灰质炎病毒疫苗病毒脱落后口服脊髓灰质炎的挑战
Review
Systematic Review of Mucosal Immunity Induced by Oral
and Inactivated Poliovirus Vaccines against Virus
Shedding following Oral Poliovirus Challenge
Thomas R. Hird, Nicholas C. Grassly*
Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, United Kingdom
so long as the average number of secondary infections generated
Abstract: Inactivated poliovirus vaccine (IPV) may be by each infected individual (the ‘‘reproduction number’’) is less
used in mass vaccination campaigns during the final than 1.
stages of polio eradication. It is also likely to be adopted Critically important to the herd immunity effect is the degree of
by many countries following the coordinated global mucosal immunity offered by vaccination against infection and
cessation of vaccination with oral poliovirus vaccine
shedding of poliovirus. The success to date of the Global Polio
(OPV) after eradication. The success of IPV in the control
Eradication Initiative (GPEI) in eliminating wild-type poliovirus
of poliomyelitis outbreaks will depend on the degree of
nasopharyngeal and intestinal mucosal immunity induced transmission from most of the world can largely be ascribed to
against poliovirus infection. We performed a systematic mass vaccination campaigns with OPV. This vaccine was chosen
review of studies published through May 2011 that not only because of the ease of administration, but also because of
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