systemic administration of igf-i enhances healing in collagenous extracellular matrices evaluation of loaded and unloaded ligaments系统性管理igf-i提高愈合的胶原细胞外矩阵评价韧带加载和卸载.pdfVIP

BMC Physiology BioMed Central Research article Open Access Systemic administration of IGF-I enhances healing in collagenous extracellular matrices: evaluation of loaded and unloaded ligaments 1 2 1,3 Paolo P Provenzano* , Adriana L Alejandro-Osorio , Kelley W Grorud , 4,5 5 6 Daniel A Martinez , Arthur C Vailas , Richard E Grindeland and Ray Vanderby Jr*1,3 Address: 1Dept. of Biomedical Engineering, University of Wisconsin, Madison, WI, USA, 2Dept. of Biomolecular Chemistry, University of Wisconsin, Madison, WI, USA, 3Dept. of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI, USA, 4Dept. Health and Human Performance, University of Houston, Houston, TX, USA, 5Dept. of Mechanical Engineering and The Biomedical Engineering Program, University of Houston, Houston, TX, USA and 6Life Sciences Research Division, NASA-Ames Research Center, Moffett Field, CA, USA Email: Paolo P Provenzano* - ppproven@; Adriana L Alejandro-Osorio - alalejandroo@; Kelley W Grorud - KGrorud@; Daniel A Martinez - ddam@Central.UH.EDU; Arthur C Vailas - availas@; Richard E Grindeland - rgrindeland@; Ray Vanderby* - vanderby@ * Corresponding authors Published: 26 March 2007 Received: 25 July 2006 Accepted: 26 March 2007 BMC Physiology 2007, 7:2 doi:10.1186/1472-6793-7-2 This article