原创力文档t cell activity in successful treatment of chronic urticaria with omalizumabt细胞活性与omalizumab成功治疗慢性荨麻疹.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
t cell activity in successful treatment of chronic urticaria with omalizumabt细胞活性与omalizumab成功治疗慢性荨麻疹
Sánchez-Machín et al. Clinical and Molecular Allergy 2011, 9:11
/content/9/1/11 CMA
COMMENTARY Open Access
T cell activity in successful treatment of chronic
urticaria with omalizumab
1 1 2 2 1
Inmaculada Sánchez-Machín , Javier Iglesias-Souto , Andrés Franco , Yvelise Barrios , Ruperto Gonzalez and
Víctor Matheu 1,3,4,5,6*
Abstract
Omalizumab, a humanized monoclonal anti-IgE antibody has the potential to alter allergen processing. Recently, it
has been postulated the assessment of PHA-stimulated adenosine triphosphate (ATP) activity as maker of CD4+ T
cells activity in peripheral blood cells. We present the case report of a 35-year-old woman with a history of chronic
idiopathic urticaria and angioedema of 8 years of development with poor response to treatment. The patient was
partially controlled with cyclosporine at doses of 100 mg/12 h. However, she was still developing hives daily.
Finally treatment with omalizumab was started at dose of 300 mg every 2 weeks. The patient experienced a
decrease in urticarial lesions 2 days after starting therapy. We also evaluated the effects of omalizumab therapy on
the activity of peripheral blood CD4+ T cells from the patient, in order to determine the potential modification of
anti-IgE therapy on the process of antigen presentation-recognition. Activity of CD4+ cells by ATP release was
clearly increased demonstrating an enlarged CD4 activity. Omalizumab may be useful in the treatment of severe
chronic urticaria. ATP activity of peripheral blood CD4+ T cells might be a non-subjective method to assess
Omalizumab activity.
We have read the interesting manuscript recently pub-
您可能关注的文档
- synthesis and catalytic activity of two new cyclic tetraaza ligands合成和催化活性的两个新的循环tetraaza配体.pdf
- synthesis and characterisation of macrocyclic diamino chiral crown ethers合成和描述的大环的二氨基手性冠醚.pdf
- synthesis and characterisation of eight isomeric bis(2-pyridyloxy)naphthalenes合成和描述的八个异构bis(2-pyridyloxy)萘.pdf
- synthesis and biological evaluation of 3-substituted-indolin-2-one derivatives containing chloropyrrole moieties合成和生物评价包含chloropyrrole根3-substituted-indolin-2-one衍生品.pdf
- synthesis and characterization of 5-nitro-2-nitratomethyl-1,2,3,4-tetrazole a high nitrogen energetic compound with good oxygen balance合成和表征5-nitro-2-nitratomethyl-1,2、3、4-tetrazole高氮高能化合物具有良好的氧平衡.pdf
- synthesis and characterization of a ru(ii) complex with functionalized phenanthroline ligands having single-double linked anthracenyl and 1-methoxy-1-buten-3-yne moieties俄文(ii)的合成和表征复杂的功能化菲罗啉配体有单键双键anthracenyl和1-methoxy-1-buten-3-yne根有关.pdf
- synthesis and characterization of acyclic and cyclic azabridged ligands incorporating 2,2'-bipyridine subunits and their complexes with copper(ii), cobalt(ii), and nickel(ii)合成和表征非循环和循环azabridged配体结合2,2u2019关于子单元和铜(ii)及其复合物,钴(ii)和镍(ii).pdf
- synthesis and characterization of carboxymethylcellulose-methacrylate hydrogel cell scaffolds合成和表征carboxymethylcellulose-methacrylate水凝胶的细胞支架.pdf
- synthesis and characterization of cationic glycidyl-based poly(aminoester)-folic acid targeting conjugates and study on gene delivery合成和表征的阳离子glycidyl-based保利(aminoester)叶酸酸研究针对轭合物和基因传递.pdf
- synthesis and characterization of azo compounds and study of the effect of substituents on their liquid crystalline behavior含氮的化合物的合成和表征和研究取代基对其液体结晶行为的影响.pdf
- systemic delays in the initiation of antiretroviral therapy during pregnancy do not improve outcomes of hiv-positive mothers a cohort study系统延迟启动抗逆转录病毒疗法在怀孕期间不能提高艾滋病毒阳性母亲一个队列研究的结果.pdf
- t cell responses to human endogenous retroviruses in hiv-1 infection人类内源性逆转录病毒hiv - 1感染的t细胞反应.pdf
- t cell responses to the rts,sas01e and rts,sas02d malaria candidate vaccines administered according to different schedules to ghanaian childrent细胞反应的rts,sas01e和rts,sas02d疟疾候选疫苗管理根据不同的时间表去加纳的孩子.pdf
- t cell targeting by anthrax toxins two faces of the same coint细胞靶向的炭疽毒素一枚硬币的两个面.pdf
- t cell subsets in hiv infected patients after successful combination antiretroviral therapy impact on survival after 12 years在艾滋病毒感染患者t细胞亚群成功联合抗逆转录病毒疗法对生存了12年的影响.pdf
- t cells contribute to tumor progression by favoring pro-tumoral properties of intra-tumoral myeloid cells in a mouse model for spontaneous melanomat细胞促进肿瘤进展通过支持pro-tumoral属性的肿瘤内髓细胞自发的黑色素瘤的小鼠模型.pdf
- t cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndromet细胞和汉坦病毒心肺综合症的发病机制与肾综合征出血热.pdf
- t cells in rheumatoid arthritist细胞在类风湿性关节炎.pdf
- t regulatory cells an overview and intervention techniques to modulate allergy outcomet调节细胞和干预技术概述调节过敏的结果.pdf
- t regulatory cells control susceptibility to invasive pneumococcal pneumonia in micet调节细胞控制容易侵入性肺炎球菌肺炎小鼠.pdf
文档评论（0）