tamm-horsfall glycoprotein enhances pmn phagocytosis by binding to cell surface-expressed lactoferrin and cathepsin g that activates map kinase pathwaytamm-horsfall糖蛋白增强中性粒细胞吞噬作用通过绑定到细胞surface-expressed乳铁蛋白和组织蛋白酶g,激活map激酶通路.pdfVIP

Molecules 2011, 16, 2119-2134; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Tamm-Horsfall Glycoprotein Enhances PMN Phagocytosis by Binding to Cell Surface-Expressed Lactoferrin and Cathepsin G That Activates MAP Kinase Pathway 1 2 2 2 3 Syue-Cian Siao , Ko-Jen Li , Song-Chou Hsieh , Cheng-Han Wu , Ming-Chi Lu , Chang-Youh Tsai 4 and Chia-Li Yu 1,2,* 1 Institute of Molecular Medicine, National Taiwan University College of Medicine, No. 7 Chung-Shan South Road, Taipei 100, Taiwan 2 Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan South Road, Taipei 100, Taiwan 3 Division of Allergy, Immunology and Rheumatology, Buddhist Dalin Tzu-Chi General Hospital, No. 2 Ming-Shen Road, Dalin, Chia-Yi, Taiwan 4 Section of Allergy, Immunology and Rheumatology, Taipei-Veterans General Hospital, No. 201 Section 2, Shih-Pai Road, Taipei 11217, Taiwan * Author to whom correspondence should be addressed; E-Mail: chialiyu@.tw; Tel.: +886-2Ext.65011; Fax: +886-2 Received: 7 December 2010; in revised form: 15 February 2011 / Accepted: 28 February 2011 / Published: 3 March 2011 Abstract: The molecular basis of polymorphonuclear neutrophil (PMN) phagocytosis-enhancing activity (PEA) by human purified urinary Tamm-Horsfall glyco- protein (THP) has not been el