原创力文档targeting vascular nadph oxidase 1 blocks tumor angiogenesis through a pparα mediated mechanism针对血管nadph氧化酶1块通过pparα介导肿瘤血管生成机制.pdfVIP
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targeting vascular nadph oxidase 1 blocks tumor angiogenesis through a pparα mediated mechanism针对血管nadph氧化酶1块通过pparα介导肿瘤血管生成机制
Targeting Vascular NADPH Oxidase 1 Blocks Tumor
Angiogenesis through a PPARa Mediated Mechanism
1 1 1 ´ 1,2 1
Sarah Garrido-Urbani , Stephane Jemelin , Christine Deffert , Stephanie Carnesecchi , Olivier Basset ,
´ 3 3 3 4 5 6
Cedric Szyndralewiez , Freddy Heitz , Patrick Page , Xavier Montet , Liliane Michalik , Jack Arbiser ,
¨ 7 1 1
Curzio Ruegg , Karl Heinz Krause , Beat Imhof *
´ ´
1 Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland, 2 Department of Pediatrics, Centre Medical
´
Universitaire, University of Geneva, Geneva, Switzerland, 3 GenKyoTex S.A., Geneva, Switzerland, 4 Department of Physiology and Metabolism, Centre Medical
Universitaire, University of Geneva, Geneva, Switzerland, 5 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland, 6 Department of Dermatology,
Emory University School of Medicine, Atlanta, Georgia, United States of America, 7 Department of Medicine, Faculty of Science, University of Fribourg, Fribourg,
Switzerland
Abstract
Reactive oxygen species, ROS, are regulators of endothelial cell migration,
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