the anti-inflammatory effects of levocetirizine - are they clinically relevant or just an interesting additional effectlevocetirizine的抗炎效应u2014u2014它们是临床相关的还是只是一个有趣的附加效果.pdfVIP

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the anti-inflammatory effects of levocetirizine - are they clinically relevant or just an interesting additional effectlevocetirizine的抗炎效应u2014u2014它们是临床相关的还是只是一个有趣的附加效果.pdf

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the anti-inflammatory effects of levocetirizine - are they clinically relevant or just an interesting additional effectlevocetirizine的抗炎效应u2014u2014它们是临床相关的还是只是一个有趣的附加效果

Allergy, Asthma Clinical Immunology BioMed Central Review Open Access The anti-inflammatory effects of levocetirizine - are they clinically relevant or just an interesting additional effect? Garry M Walsh Address: School of Medicine, University of Aberdeen, Aberdeen, UK Email: Garry M Walsh - g.m.walsh@abdn.ac.uk Published: 17 December 2009 Received: 27 October 2009 Accepted: 17 December 2009 Allergy, Asthma Clinical Immunology 2009, 5:14 doi:10.1186/1710-1492-5-14 This article is available from: /content/5/1/14 © 2009 Walsh; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Levocetirizine, the R-enantiomer of cetirizine dihydrochloride has pharmacodynamically and pharmacokinetically favourable characteristics, including rapid onset of action, high bioavailability, high affinity for and occupancy of the H1-receptor, limited distribution, minimal hepatic metabolism together with minimal untoward effects. Several well conducted randomised clinical trials have demonstrated the effectiveness of levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children. In addition to the treatment for the immediate short- term manifestations of allergic