tasco？, a product of ascophyllum nodosum, imparts thermal stress tolerance in caenorhabditis eleganstasco ascophyllum结节性的产物,传授热应力宽容在线虫.pdfVIP

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tasco？, a product of ascophyllum nodosum, imparts thermal stress tolerance in caenorhabditis eleganstasco ascophyllum结节性的产物,传授热应力宽容在线虫.pdf

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tasco？, a product of ascophyllum nodosum, imparts thermal stress tolerance in caenorhabditis eleganstasco ascophyllum结节性的产物,传授热应力宽容在线虫

Mar. Drugs 2011, 9, 2256-2282; doi:10.3390/md9112256 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article ® Tasco , a Product of Ascophyllum nodosum , Imparts Thermal Stress Tolerance in Caenorhabditis elegans Saveetha Kandasamy 1,†, Di Fan 1,†, Jatinder Singh Sangha 1,2, Wajahatullah Khan 3, Franklin Evans 2, Alan T. Critchley 2 and Balakrishnan Prithiviraj 1,* 1 Department of Environmental Sciences, Nova Scotia Agricultural College, P.O. Box 550, Truro NS B2B 5E3, Canada; E-Mails: skandasamy@nsac.ca (S.K.); fand@nsac.ca (D.F.); jsangha@nsac.ca (J.S.S.) 2 Acadian Seaplants Limited, 30 Brown Avenue, Dartmouth NS B3B 1X8, Canada; E-Mails: fevans@acadian.ca (F.E.); alan.critchley@acadian.ca (A.T.C.) 3 Genome Research Chair Unit, Department of Biochemistry, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia; E-Mail: wkhan@.sa † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: bprithiviraj@nsac.ca; Tel.: +1-902-893-6643; Fax: +1-902-895-6734. Received: 30 August 2011; in revised form: 9 October 2011 / Accepted: 24 October 2011 / Published: 8 November 2011 Abstract: Tasco®, a commercial product manufactured from the brown alga Ascophyllum nodosum, has been shown to impart thermal stress tolerance in animals. We investigated the physiological, biochemical and molecular bases of this induced thermal stress tolerance using the invertebrate animal model, Caenorhabiditis elegans. Tasco® water extract (TWE) at 300 µg/mL significantly enhance