原创力文档the bradykinin bk2 receptor mediates angiotensin ii receptor type 2 stimulated rat duodenal mucosal alkaline secretion缓激肽bk2受体介导血管紧张素ⅱ2型受体刺激大鼠十二指肠粘膜碱性分泌物.pdfVIP
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the bradykinin bk2 receptor mediates angiotensin ii receptor type 2 stimulated rat duodenal mucosal alkaline secretion缓激肽bk2受体介导血管紧张素ⅱ2型受体刺激大鼠十二指肠粘膜碱性分泌物
BMC Physiology BioMed Central
Research article Open Access
The bradykinin BK2 receptor mediates angiotensin II receptor type
2 stimulated rat duodenal mucosal alkaline secretion
Sara Ewert*, Berndt Johansson, Mathias Holm, Herbert F Helander and
Lars Fandriks
Address: Department of Gastrosurgical Research, Sahlgrenska Academy, Goteborg University, Gothenburg, Sweden
Email: Sara Ewert* - sara.ewert@gastro.gu.se; Berndt Johansson - berndt.johansson@gastro.gu.se; Mathias Holm - mathias.holm@gastro.gu.se;
Herbert F Helander - herberthelander@; Lars Fandriks - lars.fandriks@gastro.gu.se
* Corresponding author
Published: 22 February 2003 Received: 27 September 2002
Accepted: 22 February 2003
BMC Physiology 2003, 3:1
This article is available from: /1472-6793/3/1
© 2003 Ewert et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all
media for any purpose, provided this notice is preserved along with the articles original URL.
Abstract
Background: This study investigates bradykinin and nitric oxide as potential mediators of AT2-
receptor-stimulated duodenal mucosal alkaline secretion. Duodenal mucosal alkaline secretion was
measured in methohexital- and α-chloralose-anaesthetised rats by means of in situ pH-stat
titration. Immunohistochemistry and Western blot were used to identify the BK2 receptors.
Results: The AT2 receptor agonist CGP42112A (0.1 µg kg-1 min-1) administered intravenously
increased the duod
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