the contribution of the elastic reaction is severely underestimated in studies on myofibril contraction的贡献弹性反应是严重低估了在研究肌原纤维收缩.pdfVIP

Int. J. Mol. Sci. 2009, 10, 942-953; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction Enrico Grazi * and Sara Pozzati Dipartimento di Biochimica e Biologia Molecolare, Università di Ferrara, via Borsari 46, 4410 Ferrara, Italy; E-Mail: pzzsra@unife.it * Author to whom correspondence should be addressed; E-Mails: enrico.grazi@unife.it; Tel. +0039-0532-455421; Fax: +0039-0532-202723 Received: 23 January 2009; in revised form: 22 February 2009 / Accepted: 24 February 2009 / Published: 2 March 2009 Abstract: We have considered the Huxley-Simmons manoeuvre. On the assumption that the quick release is an elastic process and on the basis of the isometric tension and of the stiffness of the muscle fibre we calculated that the spontaneous release of the fibre requires ~43 μs, which is much faster than the observed release, ~180 μs. We concluded that the observed quick release is a guided process. After proper selection of the mass and of the stiffness of the system we mimicked the early recovery and noticed that most of the energy required to accomplish the early recovery is supplied by the kinetic energy accumulated during the course of the quick release. We computed that the frequency of