原创力文档the anti-repressor mecr2 promotes the proteolysis of the meca repressor and enables optimal expression of β-lactam resistance in mrsa的anti-repressor mecr2促进台面式晶体管的蛋白水解作用抑制因子,使最优表达式β-lactam耐药性的耐甲氧西林金黄色葡萄球菌.pdfVIP
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the anti-repressor mecr2 promotes the proteolysis of the meca repressor and enables optimal expression of β-lactam resistance in mrsa的anti-repressor mecr2促进台面式晶体管的蛋白水解作用抑制因子,使最优表达式β-lactam耐药性的耐甲氧西林金黄色葡萄球菌
The Anti-Repressor MecR2 Promotes the Proteolysis of
the mecA Repressor and Enables Optimal Expression of
b-lactam Resistance in MRSA
ˆ 1 2 ´ 2,3 1
Pedro Arede , Catarina Milheiric¸o , Hermınia de Lencastre , Duarte C. Oliveira *
ˆ
1 CREM, Department of Life Sciences, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, 2 Laboratory of Molecular Genetics, Instituto
´ ´
de Tecnologia Quımica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal, 3 Laboratory of Microbiology and Infectious Diseases, The Rockefeller University, New
York, New York, United States of America
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen, which is cross-resistant to virtually all
b-lactam antibiotics. MRSA strains are defined by the presence of mecA gene. The transcription of mecA can be regulated by
a sensor-inducer (MecR1) and a repressor (MecI), involving a unique series of proteolytic steps. The induction of mecA by
MecR1 has been described as very inefficient and, as such, it is believed that optimal expression of b-lactam resistance by
MRSA requires a non-functional MecR1-MecI system. However, in a recent study, no correlation was found between the
presence of functional MecR1-MecI and the level of b-lactam resistance in a representative collection of epidemic MRSA
strains. Here, we demonstrate that the mecA regulatory locus consists, in fact, of an unusual three-component arrangement
containing, in addition to mecR1-mecI, the up to now unrecognized mecR2 gene coding for an anti-rep
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