the effect of high-altitude on human skeletal muscle energetics 31p-mrs results from the caudwell xtreme everest expedition高海拔的影响对人类骨骼肌能量31 p-mrs考德威尔严酷的喜马拉雅探险的结果.pdfVIP

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the effect of high-altitude on human skeletal muscle energetics 31p-mrs results from the caudwell xtreme everest expedition高海拔的影响对人类骨骼肌能量31 p-mrs考德威尔严酷的喜马拉雅探险的结果.pdf

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the effect of high-altitude on human skeletal muscle energetics 31p-mrs results from the caudwell xtreme everest expedition高海拔的影响对人类骨骼肌能量31 p-mrs考德威尔严酷的喜马拉雅探险的结果

The Effect of High-Altitude on Human Skeletal Muscle Energetics: 31P-MRS Results from the Caudwell Xtreme Everest Expedition Lindsay M. Edwards1,2*¤a, Andrew J. Murray 1¤b, Damian J. Tyler 1,2, Graham J. Kemp3, Cameron J. Holloway2, Peter A. Robbins 1, Stefan Neubauer2, Denny Levett4, Hugh E. Montgomery4,5, Mike P. Grocott4, Kieran Clarke 1, Caudwell Xtreme Everest Research Group 1 Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 The Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom, 3 School of Clinical Sciences, University of Liverpool, Liverpool, Merseyside, United Kingdom, 4 Centre for Altitude, Space, and Extreme Environment Medicine, University College London, London, United Kingdom, 5 Institute for Human Health and Performance, University College London, London, United Kingdom Abstract Many disease states are associated with regional or systemic hypoxia. The study of healthy individuals exposed to high- altitude hypoxia offers a way to explore hypoxic adaptation without the confounding effects of disease and therapeutic interventions. Using 31P magnetic resonance spectroscopy and imaging, we investigated skeletal muscle energetics and ¨ morphology after exposure to hypobaric hypoxia in seven altitude-naıve subjects (trekkers) and seven experienced climbers. The trekkers ascended to 5300 m while the climbers ascended above 7950 m. Before the study, climbers had better mitochondrial function (evidenced by shorter phosphocreatine recovery halftime) than trekkers: 1661 vs. 2262 s (mean 6 SE, p ,0.01). Climbers had higher resting [Pi] than trekkers before the expedition and resting [Pi] was raised across both