原创力文档upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healingupregulation炎性基因sclerostin基因表达的差别,对这些关键要素的脆弱性骨折愈合的早期阶段.pdfVIP
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upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healingupregulation炎性基因sclerostin基因表达的差别,对这些关键要素的脆弱性骨折愈合的早期阶段
Upregulation of Inflammatory Genes and
Downregulation of Sclerostin Gene Expression Are Key
Elements in the Early Phase of Fragility Fracture Healing
1 1 1,2 1 ˆ ´ 1
Joana Caetano-Lopes , Ana Lopes , Ana Rodrigues , Diana Fernandes , Ines P. Perpetuo , Teresa
3,4 3,4 5 ¨ 6,7,8 ˜ 1,2. ˜
Monjardino , Raquel Lucas , Jacinto Monteiro , Yrjo T. Konttinen , Helena Canhao , Joao E.
1,2 .
Fonseca *
1 Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Lisbon, Portugal, 2 Servic¸o de Reumatologia e
´
´
Doenc¸as Osseas Metabolicas, Hospital de Santa Maria, Lisbon, Portugal, 3 Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal,
4 Institute of Public Health, University of Porto, Porto, Portugal, 5 Orthopaedics Department, Hospital de Santa Maria, Lisbon, Portugal, 6 Department of Medicine,
University of Helsinki, Helsinki, Finland, 7 ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland, 8 COXA Hospital for Joint Replacement, Tampere,
Finland
Abstract
Background: Fracture healing is orchestrated by a specific set of events that culminates in the repair of bone and
reachievement of its biomechanical properties. The aim of our work was to study the sequence of gene expression events
involved in inflammation and bone remodeling occurring in the early phases of callus formation in osteoporotic patients.
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