原创力文档up-regulation of a1mα1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage老年病的a1mα1-microglobulin皮肤血红素和活性氧使免受氧化损伤.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
up-regulation of a1mα1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage老年病的a1mα1-microglobulin皮肤血红素和活性氧使免受氧化损伤
Up-Regulation of A1M/a -Microglobulin in Skin by Heme
1
and Reactive Oxygen Species Gives Protection from
Oxidative Damage
1 1 ¨ 1 1 2
Magnus G. Olsson *, Maria Allhorn , Jorgen Larsson , Martin Cederlund , Katarina Lundqvist , Artur
2 1 ¨ 1 ˚ ¨ 1
Schmidtchen , Ole E. Sørensen , Matthias Morgelin , Bo Akerstrom
1 Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden, 2 Division of Dermatology and Venereology, Department of Clinical
Sciences, Lund University, Lund, Sweden
Abstract
During bleeding the skin is subjected to oxidative insults from free heme and radicals, generated from extracellular
hemoglobin. The lipocalin a1-microglobulin (A1M) was recently shown to have reductase properties, reducing heme-
proteins and other substrates, and to scavenge heme and radicals. We investigated the expression and localization of A1M
in skin and the possible role of A1M in the protection of skin tissue from damage induced by heme and reactive oxygen
species. Skin explants, keratinocyte cultures and purified collagen I were exposed to heme, reactive oxygen species, and/or
A1M and investigated by biochemical methods and electron microscopy. The results demonstrate that A1M is localized
ubiquitously in the dermal and epidermal layers, and that the A1M-gene is expressed in keratinocytes and up-regulated
after exposure to heme and reactive oxygen species. A1M inhibited the heme- and reactive oxygen species-induced
ultrastructu
您可能关注的文档
- the impact of different types of assistive devices on gait measures and safety in huntington's disease不同类型的辅助设备的影响在亨廷顿氏舞蹈症步态和安全措施.pdf
- the impact of anxiety-inducing distraction on cognitive performance a combined brain imaging and personality investigation使人分心的影响在认知能力结合脑成像和人格调查.pdf
- the impact of early hypoglycemia and blood glucose variability on outcome in critical illness早期低血糖和血糖变异性的影响重要疾病的结果.pdf
- the impact of different doses of vitamin a supplementation on male and female mortality. a randomised trial from guinea-bissau不同剂量的维生素a补充的影响男性和女性的死亡率。.pdf
- the impact of elbow and knee joint lesions on abnormal gait and posture of sows肘部和膝关节损伤的影响异常步态和母猪的姿势.pdf
- the impact of entropy on the spatial organization of synaptonemal complexes within the cell nucleus熵的空间组织的影响synaptonemal复合物在细胞核内.pdf
- the impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis a prospective observational study的影响符合6小时和24小时败血症包对医院死亡率严重脓毒症患者的前瞻性研究.pdf
- the impact of focused gene ontology curation of specific mammalian systems集中的影响基因本体特定的哺乳动物系统的管理.pdf
- the impact of genetic relationship information on genomic breeding values in german holstein cattle亲缘关系的影响在德国荷斯坦牛基因组育种值的信息.pdf
- the impact of empiric antimicrobial therapy with a β-lactam and fluoroquinolone on mortality for patients hospitalized with severe pneumonia经验性抗生素疗法的影响β-lactam和氟喹诺酮类患者住院重症肺炎的死亡率.pdf
- updated systematic review and meta-analysis of the performance of risk prediction rules in children and young people with febrile neutropenia更新的系统回顾和荟萃分析的风险预测的性能规则与发热性中性粒细胞减少儿童和年轻人.pdf
- updating fearful memories with extinction training during reconsolidation a human study using auditory aversive stimuli更新恐惧记忆灭绝训练在重塑人类研究使用听觉厌恶刺激.pdf
- up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice上调线粒体活动和取得的褐色脂肪组织如产权fsp27缺陷小鼠的白色脂肪组织.pdf
- up-regulation of mcl-1 and bak by coronavirus infection of human, avian and animal cells modulates apoptosis and viral replication老年病mcl1和贝克的冠状病毒感染人类,鸟类和动物细胞调节细胞凋亡和病毒复制.pdf
- upregulation of nuclear factor-related kappa b suggests a disorder of transcriptional regulation in minimal change nephrotic syndromeupregulation核factor-relatedκb显示转录调控的紊乱微小病变性肾病综合症.pdf
- up-regulation of muc2 and il-1β expression in human colonic epithelial cells by shigella and its interaction with mucins老年病muc2和il-1β表达在人类结肠上皮细胞与黏蛋白由志贺氏杆菌及其交互.pdf
- upf2 is a critical regulator of liver development, function and regenerationupf2肝脏发展是一个至关重要的监管机构,功能和再生.pdf
- upregulation of the cell-cycle regulator rgc-32 in epstein-barr virus-immortalized cellsupregulation巴尔virus-immortalized细胞循环监管者rgc-32的细胞.pdf
- upregulation of xct by kshv-encoded micrornas facilitates kshv dissemination and persistence in an environment of oxidative stressupregulation kshv-encoded xct的microrna促进kshv传播和持久性的环境中氧化应激.pdf
- upscaled ctab-based dna extraction and real-time pcr assays for fusarium culmorum and f. graminearum dna in plant material with reduced sampling error高档ctab-based dna提取和实时pcr检测枯萎culmorum和graminearum dna在植物材料减少抽样误差.pdf
文档评论（0）