uropathogenic escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial peptide ll-37uropathogenic大肠杆菌调节免疫反应及其curli菌毛与抗菌肽ll-37交互.pdfVIP
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uropathogenic escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial peptide ll-37uropathogenic大肠杆菌调节免疫反应及其curli菌毛与抗菌肽ll-37交互
Uropathogenic Escherichia coli Modulates Immune
Responses and Its Curli Fimbriae Interact with the
Antimicrobial Peptide LL-37
1a ¨ 2a 2,3 4 4 ˚ 2
Ylva Kai-Larsen , Petra Luthje , Milan Chromek , Verena Peters , Xiaoda Wang , Asa Holm , Lavinia
´ 2 5 6 7 8 ¨ 4
Kadas , Kjell-Olof Hedlund , Jan Johansson , Matthew R. Chapman , Stefan H. Jacobson , Ute Romling ,
Birgitta Agerberth1b, Annelie Brauner2*b
1 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, 2 Department of Microbiology, Tumor and Cell Biology, Division of
Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, 3 Department of Pediatrics, CLINTEC, Karolinska University Hospital and
Karolinska Institutet, Stockholm, Sweden, 4 Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden, 5 Swedish Institute for Infectious Disease Control,
Solna, Sweden, 6 Department of Anatomy, Physiology and Biochemistry, SLU, The Biomedical Centre, Uppsala, Sweden, 7 Department of Molecular, Cellular, and
Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America, 8 Department of Nephrology, Danderyd University Hospital, Karolinska
Institutet, Stockholm, Sweden
Abstract
Bacterial growth in multicellular communities, or biofilms, offers many potential advantages over single-cell growth,
including resistance to antimicrobial factors. Here we describe the interaction between the biofilm-promo
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