原创力文档ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat熊去氧胆酸与牛磺酸促进共轭secretin-stimulated胆道hydrocholeresis在正常大鼠.pdfVIP
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ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat熊去氧胆酸与牛磺酸促进共轭secretin-stimulated胆道hydrocholeresis在正常大鼠
Ursodeoxycholic Acid Is Conjugated with Taurine to
Promote Secretin-Stimulated Biliary Hydrocholeresis in
the Normal Rat
´ ´ ´ . ´ .
Miriam Uriz, Elena Saez, Jesus Prieto, Juan F. Medina* , Jesus M. Banales*
´
´ ´ ´
Division of Gene Therapy and Hepatology, CIMA Clinic and School of Medicine, University of Navarra, Centro de Investigacion Biomedica en Red en el Area tematica de
´
Enfermedades Hepaticas y Digestivas, Pamplona, Spain
Abstract
Background Aims: Secretin induces bicarbonate-rich hydrocholeresis in healthy individuals, but not in untreated patients
with primary biliary cirrhosis (PBC). Ursodeoxycholic acid (UDCA) – the first choice treatment for PBC – restores the secretin
response. Compared with humans, secretin has poor effect in experimental normal-rat models with biliary drainage,
although it may elicit hydrocholeresis when the bile-acid pool is maintained. In view of the benefits of UDCA in PBC, we
used normal-rat models to unravel the acute contribution of UDCA (and/or taurine-conjugated TUDCA) for eliciting the
biliary secretin response.
Methods: Intravascular and/or intrabiliary administration of agonists and inhibitors was performed in normal rats with
biliary monitoring. Secretin/bile-acid interplay was analyzed in 3D cultured rat cholangiocytes that formed expansive cystic
structures with intralumenal hydroionic secretion.
R
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