usp18-based negative feedback control is induced by type i and type iii interferons and specifically inactivates interferon α responseusp18-based负反馈控制是由i型和iii型干扰素干扰素α的反应,特别是使其失去活性.pdfVIP
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usp18-based negative feedback control is induced by type i and type iii interferons and specifically inactivates interferon α responseusp18-based负反馈控制是由i型和iii型干扰素干扰素α的反应,特别是使其失去活性
USP18-Based Negative Feedback Control Is Induced by
Type I and Type III Interferons and Specifically
Inactivates Interferon a Response
´ 1 2¤ ´ 1
Veronique Franc¸ois-Newton , Gabriel Magno de Freitas Almeida , Beatrice Payelle-Brogard ,
` 2 3 4 1. ´ 2 .
Daniele Monneron , Lydiane Pichard-Garcia , Jacob Piehler , Sandra Pellegrini , Gilles Uze *
´ ´
1 Institut Pasteur, Cytokine Signaling Unit, Centre National de la Recherche Scientifique, Unite de Recherche Associee 1961, Paris, France, 2 Centre National de la
´ ´ ´ ´
Recherche Scientifique, Unite Mixte de Recherche 5235, University of Montpellier II, Montpellier, France, 3 Institut National de la Sante Et de la Recherche Medicale, Unite
´ ´ ˆ ¨ ¨
1040, Universite Montpellier I, Institut de Recherche en Biotherapie, Hopital Saint Eloi, Montpellier, France, 4 Division of Biophysics, University of Osnabruck, Osnabruck,
Germany
Abstract
Type I interferons (IFN) are cytokines that are rapidly secreted upon microbial infections and regulate all aspects of the
immune response. In hu
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