verrucarin a inhibition of map kinase activation in a pma-stimulated promyelocytic leukemia cell lineverrucarin map激酶激活的抑制pma-stimulated早幼粒细胞白血病细胞系.pdfVIP

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verrucarin a inhibition of map kinase activation in a pma-stimulated promyelocytic leukemia cell lineverrucarin map激酶激活的抑制pma-stimulated早幼粒细胞白血病细胞系.pdf

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verrucarin a inhibition of map kinase activation in a pma-stimulated promyelocytic leukemia cell lineverrucarin map激酶激活的抑制pma-stimulated早幼粒细胞白血病细胞系

Mar. Drugs 2005, 3, 64-73 Marine Drugs ISSN 1660-3397 /marinedrugs/ Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line 1, 4 4 5 3 Taiko Oda *, Michio Namikoshi , Kyoko Akano , Hisayoshi Kobayashi , Yoshio Honma and 2 Tadashi Kasahara Department of 1 Basic Biological Sciences and 2 Biochemistry, and 3 Institute of Radiopharmaceutical Chemistry, Kyoritsu College of Pharmacy, Shibakoen 1-chome, 5-30, Minato-ku, Tokyo, 105-8512, Japan. 4 Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan. 5 Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113- 0032, Japan. *Author to whom correspondence should be addressed; Tel. +81-3-5400-2497, Fax +81-3-5400-2497, E-mail: oda-ti@kyoritsu-ph.ac.jp Received: 4 March 2005 / Accepted: 2 June 2005 / Published: 2 June 2005 Abstract: Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-κB activation at non- cytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin