verrucisidinol and verrucosidinol acetate, two pyrone-type polyketides isolated from a marine derived fungus, penicillium aurantiogriseum多酮类化合物verrucisidinol和醋酸verrucosidinol pyrone-type从海洋真菌,分离青霉菌aurantiogriseum.pdfVIP

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verrucisidinol and verrucosidinol acetate, two pyrone-type polyketides isolated from a marine derived fungus, penicillium aurantiogriseum多酮类化合物verrucisidinol和醋酸verrucosidinol pyrone-type从海洋真菌,分离青霉菌aurantiogriseum.pdf

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verrucisidinol and verrucosidinol acetate, two pyrone-type polyketides isolated from a marine derived fungus, penicillium aurantiogriseum多酮类化合物verrucisidinol和醋酸verrucosidinol pyrone-type从海洋真菌,分离青霉菌aurantiogriseum

Mar. Drugs 2010, 8, 2744-2754; doi:10.3390/md8112744 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum Ke Yu 1,2, Biao Ren 1,2, Junli Wei 3, Caixia Chen 1, Jinsheng Sun 3, Fuhang Song 1, Huanqin Dai 1 and Lixin Zhang 1,* 1 Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China 2 Graduate University of Chinese Academy of Sciences, Beijing 100190, China 3 Tianjin Normal University, Tianjin 300387, China * Author to whom correspondence should be addressed; E-Mail: zhanglixin@; Tel./Fax: 86-10 Received: 1 October 2010; in revised form: 22 October 2010 / Accepted: 26 October 2010 / Published: 1 November 2010 Abstract: The new secondary metabolites verrucosidinol (1) and its derivative verrucosidinol acetate (2), together with a potent neurotoxin verrucosidin (3), a congener norverrucosidin (4) and a mixture of two known phytotoxic metabolites terrestric acids (5 and 6), were isolated from the marine derived fungus Penicillium aurantiogriseum. Verrucosidinol has a ring-opened ethylene oxide moiety in the polyene -pyrone skeleton, and verrucosidinol acetate is its acetate derivative. The chemical structures were determined by comparing with literature data and a combination of spectroscopic