原创力文档vha-19 is essential in caenorhabditis elegans oocytes for embryogenesis and is involved in trafficking in oocytesvha-19至关重要的秀丽隐杆线虫卵母细胞在卵母细胞胚胎发生和参与交易.pdfVIP
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vha-19 is essential in caenorhabditis elegans oocytes for embryogenesis and is involved in trafficking in oocytesvha-19至关重要的秀丽隐杆线虫卵母细胞在卵母细胞胚胎发生和参与交易
VHA-19 Is Essential in Caenorhabditis elegans Oocytes
for Embryogenesis and Is Involved in Trafficking in
Oocytes
¤
Alison J. Knight, Nicholas M. Johnson , Carolyn A. Behm*
Research School of Biology, College of Medicine, Biology and Environment, Australian National University, Canberra, Australian Capital Territory, Australia
Abstract
There is an urgent need to develop new drugs against parasitic nematodes, which are a significant burden on human health
and agriculture. Information about the function of essential nematode-specific genes provides insight to key nematode-
specific processes that could be targeted with drugs. We have characterized the function of a novel, nematode-specific
Caenorhabditis elegans protein, VHA-19, and show that VHA-19 is essential in the germline and, specifically, the oocytes, for
the completion of embryogenesis. VHA-19 is also involved in trafficking the oocyte receptor RME-2 to the oocyte plasma
membrane and is essential for osmoregulation in the embryo, probably because VHA-19 is required for proper eggshell
formation via exocytosis of cortical granules or other essential components of the eggshell. VHA-19 may also have a role in
cytokinesis, either directly or as an indirect effect of its role in osmoregulation. Critically, VHA-19 is expressed in the
excretory cell in both larvae and adults, suggesting that it may have a role in osmoregulation in C. elegans more generally,
probably in trafficking or secretion pathways. This is the first time a role for VHA-19 has been described.
Citation: Knight AJ, Johnson NM, Behm CA (2012) VHA-19 Is Essential in Caenorhabditis elegans Oocytes for Embryogenesis and Is Involved in Trafficking in
Oocytes. PLoS ONE 7(7): e40317. doi:10.1371/journal.pone.0040317
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