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vinculin motion modes analysis with elastic network modelvinculin运动模式分析与弹性网络模型
Int. J. Mol. Sci. 2012, 13, 208-220; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Vinculin Motion Modes Analysis with Elastic Network Model
Xiong Jiao 1,*, Shan Chang 2, Lifeng Yang 3, Meiwen An 1 and Weiyi Chen 1
1 Institute of Applied Mechanics and Biomedical Engineering, Taiyuan University of Technology,
Taiyuan 030024, China; E-Mails: anmw_jx@ (M.A.); chenwy_jx@ (W.C.)
2 College of Informatics, South China Agricultural University, Guangzhou 510642, China;
E-Mail: schang@
3 College of Computer Science and Technology, College of Software, Taiyuan University of
Technology, Taiyuan 030024, China; E-Mail: yanglifeng@
* Author to whom correspondence should be addressed; E-Mail: jiaoxiong@;
Tel.: +86-351-6010818.
Received: 14 October 2011; in revised form: 11 December 2011 / Accepted: 12 December 2011 /
Published: 27 December 2011
Abstract: Vinculin is an important protein for the linkage between adhesion molecules and
the actin cytoskeleton. The activation mechanism of vinculin is still controversial. In order
to provide useful information for a better understanding of its activation, we analyze the
motion mode of vinculin with elastic network model in this work. The results show that, to
some extent, the five domains will present structural rigidity in the motion process. The
differences between the structure fluctuations of
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