原创力文档viral decay kinetics in the highly active antiretroviral therapy-treated rhesus macaque model of aids病毒衰变动力学在高效抗逆转录病毒艾滋病therapy-treated恒河猕猴模型.pdfVIP
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viral decay kinetics in the highly active antiretroviral therapy-treated rhesus macaque model of aids病毒衰变动力学在高效抗逆转录病毒艾滋病therapy-treated恒河猕猴模型
Viral Decay Kinetics in the Highly Active Antiretroviral
Therapy-Treated Rhesus Macaque Model of AIDS
1 1 1 1 1
Jesse D. Deere , Joanne Higgins , Elda Cannavo , Andradi Villalobos , Lourdes Adamson , Emilie
4 4 1,2 1,3
Fromentin , Raymond F. Schinazi , Paul A. Luciw , Thomas W. North *
1 Center for Comparative Medicine, University of California Davis, Davis, California, United States of America, 2 Department of Pathology, School of Medicine, University of
California Davis, Davis, California, United States of America, 3 Department of Veterinary Molecular Biosciences, University of California Davis, Davis, California, United States
of America, 4 Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Veterans Affairs Medical
Center, Decatur, Georgia, United States of America
Abstract
To prevent progression to AIDS, persons infected with human immunodeficiency virus type 1 (HIV-1) must remain on highly
active antiretroviral therapy (HAART) indefinitely since this modality does not eradicate the virus. The mechanisms involved
in viral persistence during HAART are poorly understood, but an animal model of HAART could help elucidate these
mechanisms and enable studies of HIV-1 eradication strategies. Due to the specificity of non-nucleoside reverse
transcriptase (RT) inhibitors (NNRTIs) for HIV-1, we have used RT-SHIV, a chimeric virus of simian immunodeficiency virus
with RT from HIV-1. This virus is susceptible to NNRTIs and causes an AIDS-like disease in rhesus macaques. In this study, two
groups of
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