原创力文档viral ctl escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute siv infection of macaques病毒ctl逃避突变体生成在淋巴结和随后成为固定在等离子体和直肠粘膜急性siv感染的猕猴.pdfVIP
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viral ctl escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute siv infection of macaques病毒ctl逃避突变体生成在淋巴结和随后成为固定在等离子体和直肠粘膜急性siv感染的猕猴
Viral CTL Escape Mutants Are Generated in Lymph Nodes
and Subsequently Become Fixed in Plasma and Rectal
Mucosa during Acute SIV Infection of Macaques
1,2 2 2 2
Thomas H. Vanderford , Chelsea Bleckwehl , Jessica C. Engram , Richard M. Dunham , Nichole R.
2 3 1 4 1,2
Klatt , Mark B. Feinberg , David A. Garber , Michael R. Betts , Guido Silvestri *
1 Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, 2 Department of Pathology and Laboratory Medicine, University
of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 3 Merck Vaccines and Infectious Diseases, Merck and Co., Inc., West Point,
Pennsylvania, United States of America, 4 Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of
America
Abstract
SIVmac239 infection of rhesus macaques (RMs) results in AIDS despite the generation of a strong antiviral cytotoxic T
lymphocyte (CTL) response, possibly due to the emergence of viral escape mutants that prevent recognition of infected
cells by CTLs. To determine the anatomic origin of these SIV mutants, we longitudinally assessed the presence of CTL escape
variants in two MamuA*01-restricted immunodominant epitopes (Tat-SL8 and Gag-CM9) in the plasma, PBMCs, lymph
nodes (LN), and rectal biopsies (RB) of fifteen SIVmac239-infected RMs. As expected, Gag-CM9 did not exhibit signs of escape
before day 84 post infection. In contrast, Tat-SL8 escape mutants were apparent in all tissues
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