原创力文档water extract from the leaves of withania somnifera protect ra differentiated c6 and imr-32 cells against glutamate-induced excitotoxicity水提取物的叶子withania somnifera保护ra分化c6和imr-32细胞免受glutamate-induced会引起.pdfVIP
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water extract from the leaves of withania somnifera protect ra differentiated c6 and imr-32 cells against glutamate-induced excitotoxicity水提取物的叶子withania somnifera保护ra分化c6和imr-32细胞免受glutamate-induced会引起
Water Extract from the Leaves of Withania somnifera
Protect RA Differentiated C6 and IMR-32 Cells against
Glutamate-Induced Excitotoxicity
1 2 2 1
Hardeep Kataria , Renu Wadhwa *, Sunil C. Kaul , Gurcharan Kaur *
1 Department of Biotechnology, Guru Nanak Dev University, Amritsar, India, 2 National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
Abstract
Glutamate neurotoxicity has been implicated in stroke, head trauma, multiple sclerosis and neurodegenerative disorders.
Search for herbal remedies that may possibly act as therapeutic agents is an active area of research to combat these
diseases. The present study was designed to investigate the neuroprotective role of Withania somnifera (Ashwagandha),
also known as Indian ginseng, against glutamate induced toxicity in the retinoic acid differentiated rat glioma (C6) and
human neuroblastoma (IMR-32) cells. The neuroprotective activity of the Ashwagandha leaves derived water extract (ASH-
WEX) was evaluated. Cell viability and the expression of glial and neuronal cell differentiation markers was examined in
glutamate challenged differentiated cells with and without the presence of ASH-WEX. We demonstrate that RA-
differentiated C6 and IMR-32 cells, when exposed to glutamate, undergo loss of neural network and cell death that was
accompanied by increase in the stress protein HSP70. ASH-WEX pre-treatment inhibited glutamate-induced cell death and
was able to revert glutamate-induced changes in HSP70 to a large extent. Furthermore, the analysis on the neuronal
plasticity marker NCAM (Neural cell adhesion molecule) and its polysialylated form, PSA-NCAM revealed that ASH-WEX has
therapeutic potential for preven
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