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when are new hippocampal neurons, born in the adult brain, integrated into the network that processes spatial information什么时候新海马神经元,出生在成年人的大脑,处理空间信息集成到网络
When Are New Hippocampal Neurons, Born in the Adult
Brain, Integrated into the Network That Processes Spatial
Information?
1 ´ 1. 1. ´ 2 ´
C. Jimena Sandoval , Marisela Martınez-Claros , Paola C. Bello-Medina , Oswaldo Perez , Vıctor
´ 1*
Ramırez-Amaya
´ ´ ´ ´
1 Laboratorio de redes neuronales plasticas, Departamento de Neurobiologıa Conductual y Cognitiva, Instituto de Neurobiologıa, Universidad Nacional Autonoma de
´ ´ ´ ´ ´ ´
Mexico, Campus Juriquilla, Queretaro Qro, Mexico, 2 Laboratorio de neurofisiologıa de la percepcion, Departamento de Neurobiologıa Conductual y Cognitiva, Instituto
´ ´ ´ ´ ´
de Neurobiologıa, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro Qro, Mexico
Abstract
Adult-born neurons in the dentate gyrus (DG) functionally integrate into the behaviorally relevant hippocampal networks,
showing a specific Arc-expression response to spatial exploration when mature. However, it is not clear when, during the 4-
to 6-week interval that is critical for survival and maturation of these neurons, this specific response develops. Therefore, we
characterized Arc expression after spatial exploration or cage control conditions in adult-born neurons from rats that were
injected with BrdU on one day and were sacrificed 1, 7, 15, 30, and 45 days post-Br
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