银杏叶片联合布地奈德吸入治疗对哮喘儿童辅助性T细胞亚群调节.docVIP

银杏叶片联合布地奈德吸入治疗对哮喘儿童辅助性T细胞亚群调节 　 作者：忻悦， 吕进泉， 吕剑平， 唐燕， 张晓鸣 【摘要】 　　目的： 观察银杏叶片联合布地奈德对哮喘儿童外周血辅助性T细胞（Th）亚群的影响。方法： 65例中、重度哮喘儿童随机分为两组：激素治疗组34例，单纯吸入布地奈德气雾剂治疗6个月；联合治疗组31例，吸入布地奈德气雾剂且同时口服银杏叶片6个月。测定治疗前后血浆中IL4，IFNγ水平，同时以20例健康儿童为正常对照组。结果： 两哮喘组治疗前、后血浆IFNγ水平均低于正常对照组（P＜0.01），治疗后IFNγ水平均高于治疗前（P＜0.01），两哮喘组治疗后IFNγ水平无明显差异（P＞0.05）；两哮喘组治疗前、后血浆IL4和IL4/IFNγ均显著高于正常对照组（P＜0.01或P＜0.05）；治疗后两组IL4和IL4/IFNγ均下降（P＜0.01），且联合治疗组低于激素治疗组（P＜0.01）。结论： 银杏叶片与布地奈德具有协同作用，联合应用更有利于纠正失衡的Th亚群。 【关键词】 哮喘； 白细胞介素4； γ干扰素； T淋巴细胞亚群； 银杏叶 　　［Abstract］Objective: To observe the effects of Ginkgo biloba tablets plus aerosol budesonide on T helper cell subsets in children with asthma.Methods： Sixtyfive children with moderate or severe asthma were randomizedly divided into two asthma groups: 34 cases were adopted as budesonide group, which were treated with inhalation of budesonide alone for 6 months，and other 31 cases were adopted as the combined therapy group, which were treated with inhalation of budesonide and oral Ginkgo biloba tablets also for 6 months. The normal control group was 20 healthy children. ELISA was used to determine the serum concentrations of IFNγ and IL4. Results： The serum concentrate ration of IFNγ before and after the treatment in the combined therapy group and the budesonide group was decreased than that of normal group(P＜0.01), and in the two asthma groups, the serum concentrate ration of IFNγ after treatment was increased than that of before treatment(P＜0.01), but the serum IFNγ in the two asthma groups after treatment had no significant difference(P＞0.05). The IL4 and IL4/IFNγ levels before and after treatment in the combined therapy group and the budesonide group were higher than those of the normal group(P＜0.01 or P＜0.05), the above levels after the treatment in the two asthma groups were lower than those before the treatment(P＜0.01), and those levels after treatment in the combined therapy group were lower than those in the budesonide group(P＜0.01). Conclusion： Ginkg