国产及进口喹硫平治疗精神分裂症对照探究.docVIP

国产及进口喹硫平治疗精神分裂症对照探究 　【摘要】 目的 比较国产与进口喹硫平治疗精神分裂症的临床疗效及安全性。 方法 将60例精神分裂症患者随机分为两组各30例，研究组口服国产喹硫平治疗，对照组口服进口喹硫平治疗，观察8 w。于治疗前及治疗1 w、8 w末采用阳性与阴性症状量表评定临床疗效，副反应量表评定不良反应。 结果 治疗8 w末，研究组显效率80.0%、总有效率96.7%；对照组分别为76.7%和100%，两组显效率、总有效率比较差异均无显著性（χ2=0.981、1.017，P＞0.05）。阳性与阴性症状量表评分，两组治疗第1 w末起总分均较治疗前有显著性下降（P均＜0.01），治疗8 w末，总分及各因子分均显著低于治疗前（P均＜0.01）。两组不良反应均轻微，主要为轻度头昏、低血压、食欲减退等。结论 国产喹硫平治疗精神分裂症的疗效、起效时间、安全性、依从性与进口喹硫平相当。 【关键词】 精神分裂症；喹硫平；国产；进口；疗效；安全性 　　A control study of domestic vs. import quetiapine in the treatment of schizophrenia 　　【Abstract】 Objective To compare the clinical efficacy and safety of domestic vs. import quetiapine in schizophrenia. Methods Sixty schizophrenivs were randomly divided into research（n=30)orally took domestic quetiapine and control group（n=30）did import quetiapine for 8 weeks. Clinical efficacies were assessed with the Positive and Negative Symptom Scale（PANSS） and adverse reactions with the Treatment Emergent Symptom Scale（TESS）at the ends of week 1 and 8，respectively. Results At the end of week 8, excellence and total effective rates were 80.0% and 96.7% in the research and 76.7% and 100% in the control group respectively,which showed no significant difference(Pgt;0.05).Since the end of week 1, total scores of the PANSS of both groups lowered much more significantly(both Plt;0.01),total and each factor score were very significantly lower at the end of week 8 compared with pretreatment(all Plt;0.01) .Adverse reactions of both groups were mild and mainly mild dizziness, hypotension, anorexia and so on. Conclussion Domestic quetiapine is significantly effective,takes effects quicker,has higher safety and better compliance, is equivalent to import quetiapine and may be clinically extended as firstline atypical antipsychotant. 　　【Keywords】 Schizophrenia；quetiapine；domestic;import;efficacy；safety 喹硫平是二苯二氮艹卓类衍生物，其结构及药理作用与氯氮平及奥氮平类似，是继氯氮平、利培酮、奥氮平之后新型非典型抗精神病药［1］，已逐渐广泛应用于精神科临床。为进一步验证国产喹硫平（舒思）与进口喹硫平（思瑞康）治疗精神分裂症的临床疗效及安全性，我们进行了相关对照研究，现报道如下。 　　1 对象与方法 　　1.1 对象 　　选取在我院住院的精