原创力文档the p2 receptor antagonist ppads supports recovery from experimental stroke in vivop2受体拮抗剂ppads支持复苏实验中风体内.pdfVIP
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the p2 receptor antagonist ppads supports recovery from experimental stroke in vivop2受体拮抗剂ppads支持复苏实验中风体内
The P2 Receptor Antagonist PPADS Supports Recovery
from Experimental Stroke In Vivo
¨ 1,2 1 3 ¨ 4 ¨ 3
Alexandra B. Lammer , Alexander Beck , Benjamin Grummich , Annette Forschler , Thomas Krugel ,
4 2 3 3 ¨ 3
Thomas Kahn , Dietmar Schneider , Peter Illes , Heike Franke , Ute Krugel *
1 Department of Neurology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany, 2 Department of Neurology, University of Leipzig, Leipzig,
Germany, 3 Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany, 4 Department of Diagnostic and Interventional Radiology,
University of Leipzig, Leipzig, Germany
Abstract
Background: After ischemia of the CNS, extracellular adenosine 59-triphosphate (ATP) can reach high concentrations due to
cell damage and subsequent increase of membrane permeability. ATP may cause cellular degeneration and death,
mediated by P2X and P2Y receptors.
Methodology/Principal Findings: The effects of inhibition of P2 receptors by pyridoxalphosphate-6-azophenyl-2 9,4 9-
disulphonic acid (PPADS) on electrophysiological, functional and morphological alterations in an ischemia model with
permanent middle cerebral artery occlusion (MCAO) were investigated up to day 28. Spontaneously hypertensive rats
received PPADS or vehicle intracerebroventricularly 15 minutes prior MCAO for up to 7 days. The functional recovery
monitored by qEEG was improved by PPADS indicated by an accelerated recovery of ischemia-induced qEEG changes in the
delta and a
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