原创力文档the p2x7 receptor is a candidate product of murine and human lupus susceptibility loci a hypothesis and comparison of murine allelic productsp2x7受体是小鼠和人类的候选产品狼疮小鼠等位基因的易感性位点假说和比较产品.pdfVIP
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the p2x7 receptor is a candidate product of murine and human lupus susceptibility loci a hypothesis and comparison of murine allelic productsp2x7受体是小鼠和人类的候选产品狼疮小鼠等位基因的易感性位点假说和比较产品
Available online /content/7/3/R468
Vol 7 No 3 Open Access
Research article
The P2X7 receptor is a candidate product of murine and human
lupus susceptibility loci: a hypothesis and comparison of murine
allelic products
James I Elliott, John H McVey and Christopher F Higgins
MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, UK
Corresponding author: James I Elliott, james.elliott@csc.mrc.ac.uk
Received: 20 Oct 2004 Revisions requested: 30 Nov 2004 Revisions received: 18 Jan 2005 Accepted: 21 Jan 2005 Published: 21 Feb 2005
Arthritis Research Therapy 2005, 7:R468-R475 (DOI 10.1186/ar1699)
/content/7/3/R468
© 2005 Elliott et al., licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/
2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Systemic lupus erythematosus and its murine equivalent, lymphocytes, NZW lymphocytes and (NZB × NZW)F1
modelled in the New Zealand Black and New Zealand White lymphocytes to P2X7 stimulation. NZB and NZW parental
(NZB × NZW)F hybrid strain, are polygenic inflammatory strains express the distinct P2X -L and P2X -P alleles of P2RX ,
1 7 7 7
diseases, probably reflecting an autoimmune response to debris
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