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the plurinetwork an electronic representation of the network underlying pluripotency in mouse, and its applicationsplurinetwork电子表示网络潜在的多能性的鼠标,和它的应用程序
The PluriNetWork: An Electronic Representation of the
Network Underlying Pluripotency in Mouse, and Its
Applications
1. 1. 2 1,3 1
Anup Som , Clemens Harder , Boris Greber , Marcin Siatkowski , Yogesh Paudel , Gregor
1,4,5 6 ¨ 2,7 1
Warsow , Clemens Cap , Hans Scholer , Georg Fuellen *
1 Institute for Biostatistics and Informatics in Medicine and Ageing Research, University of Rostock, Rostock, Germany, 2 Department of Cell and Developmental Biology,
¨
Max Planck Institute for Molecular Biomedicine, Munster, Germany, 3 DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany, 4 Institute for Anatomy
and Cell Biology, Ernst Moritz Arndt University Greifswald, Greifswald, Germany, 5 Department of Mathematics and Informatics, Ernst Moritz Arndt University Greifswald,
¨ ¨
Greifswald, Germany, 6 Department of Computer Science, University of Rostock, Rostock, Germany, 7 Medical Faculty, University of Munster, Munster, Germany
Abstract
Background: Analysis of the mechanisms underlying pluripotency and reprogramming would benefit substantially from
easy access to an electronic network of genes, proteins and mechanisms. Moreover, interpreting gene expression data
needs to move beyond just the identification of the up-/downregulation of key genes and of overrepresented processes
and pathways, towards clarifying the essential effects of the experiment in molecular terms.
Methodology/Principal Findings: We have
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