the relative importance of innate immune priming in wolbachia-mediated dengue interference先天免疫启动的相对重要性在wolbachia-mediated登革热干扰.pdfVIP
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the relative importance of innate immune priming in wolbachia-mediated dengue interference先天免疫启动的相对重要性在wolbachia-mediated登革热干扰
The Relative Importance of Innate Immune Priming in
Wolbachia-Mediated Dengue Interference
`
Edwige Rances, Yixin H. Ye, Megan Woolfit, Elizabeth A. McGraw, Scott L. O’Neill*
School of Biological Sciences, Monash University, Clayton, Australia
Abstract
The non-virulent Wolbachia strain wMel and the life-shortening strain wMelPop-CLA, both originally from Drosophila
melanogaster, have been stably introduced into the mosquito vector of dengue fever, Aedes aegypti . Each of these
Wolbachia strains interferes with viral pathogenicity and/or dissemination in both their natural Drosophila host and in their
new mosquito host, and it has been suggested that this virus interference may be due to host immune priming by
Wolbachia. In order to identify aspects of the mosquito immune response that might underpin virus interference, we used
whole-genome microarrays to analyse the transcriptional response of A. aegypti to the wMel and wMelPop-CLA Wolbachia
strains. While wMel affected the transcription of far fewer host genes than wMelPop-CLA, both strains activated the
expression of some immune genes including anti-microbial peptides, Toll pathway genes and genes involved in
melanization. Because the induction of these immune genes might be associated with the very recent introduction of
Wolbachia into the mosquito, we also examined the same Wolbachia strains in their original host D. melanogaster. First we
demonstrated that when dengue viruses were injected into D. melanogaster, virus accumulation was significantly reduced in
the presence of Wolbachia, just as in A. aegypti. Second, when we carried out transcriptional analyses of the same immune
genes up-regulated in the new heterologou
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