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the role of lipids in retrovirus replication脂质在逆转录病毒复制的作用
Viruses 2010, 2, 1146-1180; doi:10.3390/v2051146
OPEN ACCESS
viruses
ISSN 1999-4915
/journal/viruses
Review
The Role of Lipids in Retrovirus Replication
Abdul A. Waheed * and Eric O. Freed
Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick,
MD 21702, USA
* Author to whom correspondence to be addressed; E-Mail: awaheed@;
Tel.: +1-301-846-1739; Fax: +1-301-846-6777.
Received: 22 March 2010; in revised form: 23 April 2010 / Accepted: 27 April 2010 /
Published: 6 May 2010
Abstract: Retroviruses undergo several critical steps to complete a replication cycle.
These include the complex processes of virus entry, assembly, and budding that often take
place at the plasma membrane of the host cell. Both virus entry and release involve
membrane fusion/fission reactions between the viral envelopes and host cell membranes.
Accumulating evidence indicates important roles for lipids and lipid microdomains in virus
entry and egress. In this review, we outline the current understanding of the role of lipids
and membrane microdomains in retroviral replication.
Keywords: retroviruses; phospholipids; sphingolipids; cholesterol; PI(4,5)P2 ; lipid rafts;
entry; assembly; budding
1. Introduction
Retroviruses comprise a diverse group of enveloped RNA viruses that cause
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